Vladimir Putin““We discussed this important issue yesterday over a beer...” ”
Barack OBAMA“You know, my faith is one that admits some doubt...”
Type 2 Diabetes Under Stress
Type 2 diabetes is caused by an inability of the beta-cells in the pancreas to produce enough of the hormone insulin to meet the body’s needs.
Central to this is a loss of beta-cell function and mass as a result of insulin resistance (the inability of cells in the body to respond appropriately to insulin).
New insight into how insulin resistance leads to loss of beta-cell mass has now been provided by studies in multiple mouse models of type 2 diabetes performed by Randal Kaufman and colleagues, at the University of Michigan Medical School, Ann Arbor.
In the study, in the absence of the protein CHOP, the symptoms of diabetes improved in two mouse models of the disease, and this was associated with increased beta-cell mass. In addition, the structure of the beta-cells appeared to be more normal and they were encouraged to survive.
CHOP is a protein that is involved in promoting the death of a cell that is under stress because it is producing more protein than it is able to handle.
The authors therefore propose that insulin resistance causes beta-cells to make more insulin than they can handle, such that the stress signaling pathways that activate CHOP are initiated and the beta-cells die, thereby decreasing beta-cell mass. Further, it is suggested that drugs that modulate the stress response to over production of insulin might provide a new approach to the treatment of type 2 diabetes.
Leave a Reply
Advanced Random Articles
UPDATE: Justin Timberlake: Busted Cheating by Lindsay Lohan?- Paris Hilton insists she plugged sorority movie
![](http://cdn.celebuzz.com/cb/assets/imgx/3/9/1/9/2/5/1/mob-3919251.jpg?v=1263252578 "Noah Cyrus Turns 10, Gets a Jump on "Fashion Icon" Status")
Noah Cyrus Turns 10, Gets a Jump on "Fashion Icon" Status- Proposal gives shareholders non-binding say on exec pay
First human-to-human transfer of swine flu in Britain as test results show friend of Scottish newlyweds DOES have virusCould Palin flap be Letterman’s Hugh Grant?
- Chiefs sign DE Jackson
Subscribe To Got Access Feed
Most Read
Avatar SCI-FI blockbuster is fastest to hit billion
50 CENT wants to sign Jamelia
Boyz II Men & Disney’s First Black Princess
Monica: ‘Still Standing’ with New BET Reality Show and Forthcoming Music
Choreographer Travis Payne Talks About ‘Michael Jackson’s This Is It
Jay-Z: Down With Young Jeezy For 2009 BET Hip Hop Awards
So, Joe, what first attracted you to Kristina? Strictly dancer puts curves on show in low-cut dress
Victoria Beckham zips through the airport in bizarre leggings
Lamar Odom and Khloe Kardashian Wedding Pics
Elvis Presley lives on as lookalike teenage grandson Benjamin scores $5m record deal
The King of Pop Michael Jackson is dead
- [About]
- [Billboard R&B]
- [Resources]
- [RSS Feed]